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What is Zyprexa (Olanzapine)?Treatment of exacerbations, maintenance and long-term preventive treatment of schizophrenia and other psychotic disorder with marked productivity (including delusions, hallucinations, automatism) and / or negative (including emotional flattening, decreased social activity, depletion of speech) symptoms, and concomitant affective disorders;
Treatment of acute manic or mixed episodes in bipolar affective disorder with / without psychotic symptoms and with / without rapid phase change.
Film-coated tablets, round, white, imprinted with appropriate identification on one side of the main active ingredient Olanzapine.
Contraindications.Hypersensitivity to the drug.
Zyprexa (Olanzapine) Side EffectsVery common (> = 10%): drowsiness, weight gain. In 34% of patients, an increase in prolactin concentrations in plasma, which was poorly marked and transient (mean maximum concentrations of prolactin did not reach the upper limit of normal and statistically not significantly different from placebo). Clinical manifestations of hyperprolactinemia associated with olanzapine (ie, gynecomastia, galactorrhea, breast enlargement), are rare. The majority of patients with normalization of prolactin levels was observed without abolition of Olanzapine.
Another very common (> = 10%) side effects associated with Olanzapine in clinical trials in patients with Alzheimer's type dementia were gait disturbance.
Frequently (<10% and> = 1%): dizziness, fatigue, akathisia, increased appetite, peripheral edema, orthostatic hypotension, dry mouth, constipation. Occasionally there was a transient, asymptomatic increase in liver transaminases (ALT, AST), and in rare cases - raising the level of glucose in the blood plasma to> = 200 mg / dl (suspected diabetes), and> = 160 mg / dL but <200 mg / dl (suspected hyperglycemia) in patients with baseline glucose <= 140 mg / dL, some patients had asymptomatic eosinophilia.
Overdose of Zyprexa (Olanzapine)Symptoms: Very common (> = 10%) - tachycardia, agitation / aggression, articulation disorder, various extrapyramidal disorders and disturbances of consciousness of varying severity (from sedation to coma). Other clinically significant effects of olanzapine overdose include delirium, seizures, neuroleptic malignant syndrome, respiratory depression, aspiration, hypertension or hypotension, cardiac arrhythmias (<2% of cases of overdose), and cardiac arrest and respiratory system. The minimum dose for acute overdose with a fatal outcome was 450 mg maximum dose of an overdose with favorable outcome (survival) - 1500 mg.
Treatment: No specific antidote for olanzapine does not exist. Artificially induce vomiting is not recommended. Showing the standard methods of detoxification (ie gastric lavage, activated charcoal). Simultaneous treatment with activated charcoal reduces the bioavailability of olanzapine ingestion of 50-60%.
Displaying symptomatic treatment in accordance with the clinical status and control functions of vital organs, including the treatment of hypotension, circulatory collapse and support of respiratory function. You should not use epinephrine, dopamine and other sympathomimetic, which are the b-adrenergic agonists, as Stimulation of the latter may worsen hypotension.
Dosage and administration Zyprexa (Olanzapine)In schizophrenia and related psychotic disorders, the recommended initial dose is 10 mg 1 time / day. Zyprexa can be taken regardless of meals. The therapeutic dose range in the range of 5-20 mg / day. The daily dose should be individualized depending on the clinical condition of the patient. Increasing the dose above the standard is 10 mg / day is recommended only after a clinical examination of the patient.
In acute mania in bipolar disorder recommended initial dose is 15 mg 1 time / day. Therapeutic doses range Olanzapine in the range 5-20 mg / day. The daily dose should be individualized depending on the clinical condition of the patient. Increasing the dose above the standard of 15 mg / day is recommended only after a clinical examination of the patient. Increasing the dose should be gradually, at intervals of at least 24 hours.
Elderly patients, as well as severe renal insufficiency or deficiency of the liver of moderate drug administered at an initial dose of 5 mg / day.
Reducing the initial dose is recommended for patients with a combination of factors (female patients, elderly, non-smokers), in which may slow metabolism of Olanzapine.
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